A NOVEL CELL-BASED SCREEN IDENTIFIES CHEMICAL ENTITIES THAT REVERSE THE IMMUNE-ESCAPE PHENOTYPE OF METASTATIC TUMOURS

A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours

Genetic and epigenetic events have been implicated in the downregulation of the cellular antigen processing and presentation machinery (APM), which in turn, has been associated with cancer evasion of the immune system.When these essential components are lacking, cancers develop the ability to subvert host immune surveillance allowing cancer cells t

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Validation and marker-assisted selection of DArT-genomic regions associated with wheat yield-related traits under normal and drought conditions

Quantitative trait loci (QTL) is one of the most important steps in marker-assisted selection.Few studies have validated quantitative trait loci for marker-assisted selection of yield traits under drought stress conditions in wheat.A set of 138 highly diverse wheat genotypes were tested under normal and drought stress conditions for 2 years.Plant h

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Genome-wide functional annotation of variants: a systematic review of state-of-the-art tools, techniques and resources

The recent advancement of sequencing technologies marks a significant shift in the character and complexity of the digital genomic data universe, encompassing diverse types of molecular data, screened through manifold technological platforms.As a result, a plethora of fully assembled genomes are generated that span vertically the evolutionary scale

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